The SARS-CoV-2 accessory protein ORF10 (organism Human herpesvirus 8/HHV-8), a putative 38-amino acid viral protein encoded in the 3’ accessory region of the genome, is a highly ordered, hydrophobic (insoluble in water; repelling water) , and thermally stable protein, which contains at least one transmembrane region.
“the ORF10 protein contains high numbers of promiscuous cytotoxic T lymphocyte (CTL) epitopes, primarily on the α-helix. A recent study by Liu et al. 2020 found that in severe cases of COVID-19, the ORF10 was overexpressed when compared against ORF10 expression levels in moderate cases. If the ORF10 protein is synthesized (manufactured, man made), this may help to partially explain the nature behind severe cases of COVID-19. The large number of CTL epitopes in conjunction with the overproduction of the ORF10 protein could result in elevated immune responses towards SARS-CoV-2, leading to some potentially fatal immunopathological outcomes. … Alternatively, ORF10 may act itself or serve as a precursor for other RNAs in regulating gene expression/replication, translation efficiency, or interfering with cellular antiviral pathways. ” October 2020 study
ORF8, “although non-essential and the precise functions are unknown, it has been suggested that this protein assists in SARS-CoV-2 replication in the early secretory pathway and in immune evasion. … Since ORF8 is not an essential protein for the SARS-CoV-2 life cycle, ORF8 is likely to functionally associate with other SARS-CoV-2 components to assist with SARS-CoV-2 replication and assembly in host cells, but, the coordinated process of this mechanism is still unknown”
“It is also noteworthy that ORF10, exclusively found in SARS-CoV-2 (and not in SARS-CoV), has been shown to interact with the Cullin 2 (CUL2) RING E3 ligase complex, possibly hijacking its function. It is not known what the implications of this interaction is for virus replication, but a similar complex is recruited by other viral proteins, including HIV Vif, Adenovirus E4Orf6, EBV Bzlf and others (Mahon et al., 2014). In all cases, the virus exploits this to target an antiviral protein for proteasome degradation, and it is therefore likely the case also for Orf10.” Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be
Accessory proteins (ORF8, ORF10) were suggested to play an important role in virulence and host interaction in other coronaviruses (Liu et al., 2014).
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi’s sarcoma-associated herpesvirus)
Human herpesvirus 8 (HHV-8) is the infectious cause of Kaposi sarcoma (KS) and HIV-infection. HHV-8 infection is not very common in North America. It occurs more often in some Mediterranean countries and is widespread in Africa.
“In the United States, men who have sex with men (MSM) and persons with HIV infection are at increased risk for HHV-8 infection. Among MSM without HIV infection, the seroprevalence ranges from 13% to 20% and HHV-8 seroprevalence increases to 30% to 35% among MSM with HIV infection. Injection drug use may also be a risk factor for HHV-8 seropositivity, although this association has not been consistently observed.”
“HHV-8 is etiologically associated with all forms of Kaposi sarcoma (KS) including classic, endemic (belonging or native to a particular people or country), transplant-related, and AIDS-related, as well as rare neoplastic disorders (primary effusion lymphoma [PEL] and solid organ variants) and the lymphoproliferative disorder known as multicentric Castleman’s disease (MCD). Although the precise pathogenesis for these tumors remains unclear, infection with HHV-8 precedes their development.” Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV
The presence of two accessory proteins, ORF8 and ORF10, that share no homology to other coronaviruses strains but appear to assist with SARS-CoV-2 replication and and in immune evasion, suggests SARS-CoV-2 was developed for the strapped for cash WHO as a bioweapon.
ORF10 protein “HHV-8 mostly causes disease mainly in immunocompromised individuals” Johns Hopkins Medicine