2005 study proved Chloroquine / Hydroxychloroquine is a potent inhibitor of SARS-CoV infection and spread

Barry & Honey Sherman murders were, “in my view, committed by a very sophisticated organization – at least it has those hallmarks.” Supreme Court Justice Michael Moldaver, October 6, 2020 Source: The Chronicle Herald

Supreme Court documents suggests the UN had motive for the targeted murders of Barry and Honey Sherman.. The official / legal name for the UN is the United Nations Organization. The official name for the WHO is the World Health Organization. What motive did the UN Organization have to target and kill Barry and Honey Sherman? Apotex’s cheap and effective anti-SARS-CoV drug Hydroxychloroquine. The Apotex drug threatened to prematurely end Germany and the WHO’s COVID-19 biological warfare attack and defund the bankrupt / insolvent UN Organization and its lucrative multi $billion global vaccine agenda.

It is important to note that Germany and the WHO began planning for the COVID-19 plandemic in 2017. Recruited G20 leaders at the 2017 G20 Hamburg summit 5 months before the targeted murders of Apotex pharmaceutical owners Barry and Honey Sherman by using Germany and WHO produced pandemic simulation exercise videos. The videos depicted a novel SARS coronavirus outbreak that spreads by droplets. Germany and the WHO named the fictional coronavirus MARS. Germany and the WHO’s simulation exercises used fake news reports, fake Twitter posts, videos and paid actors.

“We conducted a simulation exercise during our meeting in Berlin in May 2017 in close cooperation with the World Health Organization (WHO), … The international community needs to fully support the WHO in order for the organization to be able to fulfill its role, including in capacity building and in preparing for and responding to health emergencies. In this respect, we acknowledge that WHO’s financial and human resource capacities have to be strengthened, including through adequate and sustainable funding for the Health Emergencies Programme and the WHO Contingency Fund for Emergencies (CFE).” Berlin Declaration of the G20 Health Ministers

Excerpt from Germany and the WHO’s COVID-19 plandemic manual “The 5C Health Emergency Simulation Exercise Package”

A 2005 medical study told you why Barry and Honey Sherman’s Hydroxychloroquine drug threatened the UN Organization:

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

In order to investigate if chloroquine might prevent SARS-CoV infection, permissive Vero E6 cells were pretreated with various concentrations of chloroquine (0.1–10 μM) for 20–24 h prior to virus infection. Cells were then infected with SARS-CoV, and virus antigens were visualized by indirect immunofluorescence as described in Materials and Methods. Microscopic examination (Fig. 1A) of the control cells (untreated, infected) revealed extensive SARS-CoV-specific immunostaining of the monolayer. A dose-dependant decrease in virus antigen-positive cells was observed starting at 0.1 μM chloroquine, and concentrations of 10 μM completely abolished SARS-CoV infection. For quantitative purposes, we counted the number of cells stained positive from three random locations on a slide. The average number of positively stained control cells was scored as 100% and was compared with the number of positive cells observed under various chloroquine concentrations (Fig. 1B). Pretreatment with 0.1, 1, and 10 μM chloroquine reduced infectivity by 28%, 53%, and 100%, respectively. Reproducible results were obtained from three independent experiments. These data demonstrated that pretreatment of Vero E6 cells with chloroquine rendered these cells refractory to SARS-CoV infection.

The infectivity of coronaviruses other than SARS-CoV are also affected by chloroquine, as exemplified by the human CoV-229E. The inhibitory effects observed on SARS-CoV infectivity and cell spread occurred in the presence of 1–10 μM chloroquine, which are plasma concentrations achievable during the prophylaxis and treatment of malaria (varying from 1.6–12.5 μM) [26] and hence are well tolerated by patients.

Chloroquine, a relatively safe, effective and cheap drug used for treating many human diseases including malaria, amoebiosis and human immunodeficiency virus is effective in inhibiting the infection and spread of SARS CoV in cell culture. The fact that the drug has significant inhibitory antiviral effect when the susceptible cells were treated either prior to or after infection suggests a possible prophylactic and therapeutic use.

Study published 22 August 2005 in Virology Journal

Study Affiliations

Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, 110 Pine Ave West, QCH2W1R7, Canada
Eric Bergeron, Suzanne Benjannet & Nabil G Seidah