Herpes virus ORF10 protein encoded in SARS-CoV-2 and in Pfizer–BioNTech and Moderna COVID-19 mRNA vaccines cause of all cases of COVID-19

Within SARS-CoV-2 and COVID-19 mRNA vaccines is a protein called ORF10 protein. Studies have concluded that ORF10 acts as a precursor of additional RNAs in roles concerning gene expression, controlling cellular antiviral pathways, or within viral replication (Taiaroa et al., 2020). ORF10 of SARS-CoV-2 is the last predicted coding sequence upstream of the poly-A tail and is the shortest predicted coding sequence, composed of 38 a.a. (Taiaroa et al., 2020). ORF10 is predicted to harbor a long helix and a pair of ϐ-strands. ORF10 is not found within the SARS-CoV-1 proteome (Taiaroa et al., 2020). ORF10 is the only protein that is present exclusively/only in SARS-CoV-2 and not in SARS-CoV or any other human coronaviruses.

The WHO reported that the severity of COVID-19 is enhanced by the ORF10 protein. “These findings of uniqueness of ORF10 and predicted intrinsic characteristics support possible involvement of ORF10 protein in giving COVID-19 its specific characteristics like spread and virulence.” World Heath Organization

Virulence is a pathogen’s or microorganism’s ability to cause damage to a host. In most contexts virulence refers to the degree of damage caused by a microbe to its host. The pathogenicity of an organism — its ability to cause disease — is determined by its virulence factors.

These results indicate that ORF10, like its HSV-1 homolog VP16, is a transactivating protein despite the absence of sequences similar to the VP16 carboxy-terminal domain. The transactivating function of the ORF10 tegument protein may be critical for efficient initiation of viral infection.

1993 Journal of Virology published study

We conclude that ORF10 protein is required for efficient virion assembly and is a specific determinant of virulence in epidermal and dermal cells in vivo. … ORF10 protein has some, but not all, of the properties of HSV-1 VP16. … In summary, these experiments show that ORF10 protein is required for efficient viral replication, virion formation, and cell-cell spread in human.

2006 Journal of Virology published study

Nuclear export of host mRNAs is critical for proper cellular functions and survival. To mitigate this effort, viruses have evolved multiple strategies to inhibit this process. Distinct to the generally nonselective inhibition mechanisms, ORF10 from gammaherpesviruses blocks nuclear export of selective mRNAs by forming a complex with Rae1 (RNA export 1) and Nup98 (nucleoporin 98).

October 8, 2020 published research article – Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10

Viruses have evolved multiplemechanisms to inhibit cellular gene expression, thereby impeding host antiviral responses. Gong et al. identify a herpesvirus protein, ORF10, of KSHV that blocks nuclear export of selective mRNAs by interacting with an RNA export factor, Rae1. This interaction of ORF10 is critical for optimal KSHV replication.

We report that ORF10 inhibits mRNA export in a transcript-selective manner to control cellular gene expression. Nuclear export inhibition by ORF10 requires an interaction with an RNA export factor, Rae1. Genome wide analysis reveals a subset of cellular mRNAs whose nuclear export is blocked by ORF10 with the 3’UTRs of ORF10 targeted transcripts conferring sensitivity to export inhibition. The ORF10-Rae1 interaction is important for the virus to express viral genes and produce infectious virions.

2016 study “A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export

It is important to note that all viruses and virus proteins must have a unique nomenclature (name). “Consistent protein nomenclature is indispensable for communication, literature searching and entry retrieval. A good protein name is one which is unique, unambiguous, can be attributed to orthologs from other species and follows official gene nomenclature where applicable. The process of associating a name with a protein sequence has various components: sequence function identification/prediction, choosing a name and applying formatting.International Protein Nomenclature Guidelines

ORF10 protein is a protein of the human herpes virus. Herpesviruses are large DNA viruses that have two distinct life cycle phases: lytic replication and latency. During lytic replication, they operate a highly regulated viral gene expression program, resulting in the production of infectious virions. Herpesviruses are known for manipulating cellular mRNA export machinery.

The COVID-19 mRNA vaccines contain both the herpes virus protein ORF10 and instructions to make spike proteins to give the herpes virus protein ORF10 the key/means to enter cells and make us sick.

mRNA vaccines teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies…. COVID-19 mRNA vaccines give instructions for our cells to make what is called the spike protein.’ The spike protein is found on the surface of the virus that causes COVID-19.” CDC

Specifically, the vaccine contains the mRNA of what’s known as spike protein, which is located on the surface of the SARS-CoV-2 virus and is what it uses to invade host cells. The novel coronavirus uses spike protein like a key to gain entry to our cells; once inside, the virus is free to replicate, making us sick.” Carlos Malvestutto, MD, MPH, who specializes in infectious disease at The Ohio State University Wexner Medical Center

Germany (BioNTech vaccine) and the WHO chose to use the 2003 patented (patent US-2006257852-A1) herpes ORF10 protein encoded SARS-CoV-2 virus to ensure the novel coronavirus would reinfect (relapse) everyone who was vaccinated for years to come. There is currently no cure or preventive treatment for a herpes infection. If a person gets a herpes virus infection, they will have it for life , whether or not they experience symptoms – during the first herpes outbreak (called primary herpes), an infected person may experience flu-like symptoms. These include body aches, fever and headache.

#COVID-19, #mRNAvaccines, #vaccines, #BioNTech, #Moderna, #WHO, #SARS-CoV-2

Imperative RCMP, police or national forensic lab test Germany’s Pfizer-BioNTech vaccine

BioNTech SEC filing for Pfizer-BioNTech COVID-19 vaccine

It is imperative RCMP, police or national forensic lab(s) test Germany’s Pfizer-BioNTech vaccine. Test to determine whether or not Germany substituted the vaccine that the FDA approved with a vaccine that would and have caused Canadians to become sick. Canadians who have gotten the 2nd Pfizer-BioNTech vaccine have become ill. I personally know 3 people who became very sick immediately after getting the 2nd Pfizer-BioNTech vaccine. All three never got sick last year.

Canadians can’t trust Germany or the WHO. Germany and the WHO desperately needs $billions to avert economic collapse. Before COVID-19 both Germany’s EU and the UN publicly stated that they were insolvent.

A Europen Commission paper reported Germany’s COVID-19 vaccine manufacturer falsified data in order to obtain regulatory approval – needed to make $billions.

“DISHONEST SCIENTIFIC REPORT AND DATA FALSIFICATION WITH RESPECT TO THE EFFECTIVENESS OF THE CANDIDATE SARS-COV-2/COVID-19 VACCINES DEVELOPED BY BIONTECH/PFIZER,”

COVID-19 isn’t the first time a Germany manufacturer intentionally falsified data. Germany’s Volkswagen falsified emission reports. Volkswagen has been conspiring with Germany since WWII to form a Germany economic Empire – the EU.

A declassified three-page, US Military Intelligence report EW-Pa 128 (Red House Report), detailed how German industrialists were to work with the Nazi Party to rebuild Germany’s economy empire / the Fourth Reich EU. Volkswagen was specifically named as one of Germany’s co-conspirators.

Furthermore, Germany’s COVID-19 vaccine manufacturing partner Pfizer plead guilty and paid $2.3 billion in 2009 to settle civil and criminal charges that it had illegally marketed its painkiller Bextra. It was the largest health care fraud settlement and the largest criminal fine of any kind ever.

Pfizer “used advisory boards, consultant meetings and provided travel to lavish resorts to improperly promote Bextra to doctors and made misleading claims about the drug’s safety and efficacy” US Department of Justice

Source: https://www.reuters.com/article/us-pfizer-settlement-idUSTRE5813XB20090902

Pfizer also illegally promoted several other drugs, including antipsychotic drug Geodon, antibiotic Zyvox, and anti-epileptic drug Lyrica. Healthcare providers received payments for prescribing these drugs to patients for off-label use.

False claims were submitted to government healthcare programmes, bypassing the insurance programmes. The company had to pay approximately $1bn to Medicare, Medicaid, and other government insurance programmes under the settlement.

Source

Germany’s Pfizer-BioNTech vaccines, in every practical sense, were developed to make SARS-CoV-2 more transmissible and infectious

Coronaviruses are surrounded by a fatty membrane known as an envelope. In order to gain entry to the inside of the cell, enveloped viruses use spike proteins to fuse their own membrane to that of cells’ and take over the cell. “The spike protein is found on the surface of the virus that causes COVID-19.” the CDC

Germany’s Pfizer-BioNTech COVID-19 mRNA vaccines give instructions for our cells to make “spike protein” – lots of them.  2nd vaccine causes the making of more spike protein. The Pfizer-BioNTech COVID-19 vaccine uses modified messenger RNA (mRNA). “Specifically, the vaccine contains the mRNA of spike protein, which is located on the surface of the SARS-CoV-2 virus and is what SARS-CoV-2 uses to invade host cells.” Carlos Malvestutto, MD, MPH, who specializes in infectious disease at The Ohio State University Wexner Medical Center

The WHO, CDC and other health authorities know and have repeatedly stated that the “novel coronavirus uses spike protein like a key to gain entry to our cells; once inside, the virus is free to replicate, making us sick. The spike protein binds to a protein on the surface of our cells called ACE2, triggering uptake of the virus particle and eventually membrane fusion.”

That means Germany’s COVID-19 vaccines were developed to make spike protein and give the SARS-CoV-2 virus the means to invade cells and cause millions of healthy people to become sick. SARS-CoV-2 can’t invade cells and make us sick without spike (S) protein. Germany’s Pfizer-BioNTech vaccines, in every practical sense, is making SARS-CoV-2 more transmissible and infectious.

The WHO, CDC, Health Canada  and Germany would have you believe that Germany’s vaccines that instruct cells to make SARS-CoV-2’s spike protein is harmless yet they all know SARS-CoV-2 needs the spike protein to invade cells to replicate and make you sick. Furthermore, “mRNAs are created as an exact copy (a clone) of the segment of DNA found along the genome corresponding to a protein-coding gene.” UMass Medical School “Specifically, the Pfizer-BioNTech COVID-19 vaccine is a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine. The lipid coating of the nanoparticles binds to the cell membrane, facilitating entry of the (SARS-CoV-2) mRNA (genetic material) segment into the cell.” AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE (ASRM).