Herpes virus ORF10 protein encoded in SARS-CoV-2 and in Pfizer–BioNTech and Moderna COVID-19 mRNA vaccines cause of all new cases of COVID-19

Within SARS-CoV-2 and COVID-19 mRNA vaccines is a protein called ORF10 protein. Studies have concluded that ORF10 acts as a precursor of additional RNAs in roles concerning gene expression, controlling cellular antiviral pathways, or within viral replication (Taiaroa et al., 2020). ORF10 of SARS-CoV-2 is the last predicted coding sequence upstream of the poly-A tail and is the shortest predicted coding sequence, composed of 38 a.a. (Taiaroa et al., 2020). ORF10 is predicted to harbor a long helix and a pair of ϐ-strands. ORF10 is not found within the SARS-CoV-1 proteome (Taiaroa et al., 2020). ORF10 is the only protein that is present exclusively/only in SARS-CoV-2 and not in SARS-CoV or any other human coronaviruses.

The WHO reported that the severity of COVID-19 is enhanced by the ORF10 protein. “These findings of uniqueness of ORF10 and predicted intrinsic characteristics support possible involvement of ORF10 protein in giving COVID-19 its specific characteristics like spread and virulence.” World Heath Organization

Virulence is a pathogen’s or microorganism’s ability to cause damage to a host. In most contexts virulence refers to the degree of damage caused by a microbe to its host. The pathogenicity of an organism — its ability to cause disease — is determined by its virulence factors.

These results indicate that ORF10, like its HSV-1 homolog VP16, is a transactivating protein despite the absence of sequences similar to the VP16 carboxy-terminal domain. The transactivating function of the ORF10 tegument protein may be critical for efficient initiation of viral infection.

1993 Journal of Virology published study

We conclude that ORF10 protein is required for efficient virion assembly and is a specific determinant of virulence in epidermal and dermal cells in vivo. … ORF10 protein has some, but not all, of the properties of HSV-1 VP16. … In summary, these experiments show that ORF10 protein is required for efficient viral replication, virion formation, and cell-cell spread in human.

2006 Journal of Virology published study

Nuclear export of host mRNAs is critical for proper cellular functions and survival. To mitigate this effort, viruses have evolved multiple strategies to inhibit this process. Distinct to the generally nonselective inhibition mechanisms, ORF10 from gammaherpesviruses blocks nuclear export of selective mRNAs by forming a complex with Rae1 (RNA export 1) and Nup98 (nucleoporin 98).

October 8, 2020 published research article – Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10

Viruses have evolved multiplemechanisms to inhibit cellular gene expression, thereby impeding host antiviral responses. Gong et al. identify a herpesvirus protein, ORF10, of KSHV that blocks nuclear export of selective mRNAs by interacting with an RNA export factor, Rae1. This interaction of ORF10 is critical for optimal KSHV replication.

We report that ORF10 inhibits mRNA export in a transcript-selective manner to control cellular gene expression. Nuclear export inhibition by ORF10 requires an interaction with an RNA export factor, Rae1. Genome wide analysis reveals a subset of cellular mRNAs whose nuclear export is blocked by ORF10 with the 3’UTRs of ORF10 targeted transcripts conferring sensitivity to export inhibition. The ORF10-Rae1 interaction is important for the virus to express viral genes and produce infectious virions.

2016 study “A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export

It is important to note that all viruses and virus proteins must have a unique nomenclature (name). “Consistent protein nomenclature is indispensable for communication, literature searching and entry retrieval. A good protein name is one which is unique, unambiguous, can be attributed to orthologs from other species and follows official gene nomenclature where applicable. The process of associating a name with a protein sequence has various components: sequence function identification/prediction, choosing a name and applying formatting.International Protein Nomenclature Guidelines

ORF10 protein is a protein of the human herpes virus. Herpesviruses are large DNA viruses that have two distinct life cycle phases: lytic replication and latency. During lytic replication, they operate a highly regulated viral gene expression program, resulting in the production of infectious virions. Herpesviruses are known for manipulating cellular mRNA export machinery.

The COVID-19 mRNA vaccines contain both the herpes virus protein ORF10 and instructions to make spike proteins to give the herpes virus protein ORF10 the key/means to enter cells and make us sick.

mRNA vaccines teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies…. COVID-19 mRNA vaccines give instructions for our cells to make what is called the spike protein.’ The spike protein is found on the surface of the virus that causes COVID-19.” CDC

Specifically, the vaccine contains the mRNA of what’s known as spike protein, which is located on the surface of the SARS-CoV-2 virus and is what it uses to invade host cells. The novel coronavirus uses spike protein like a key to gain entry to our cells; once inside, the virus is free to replicate, making us sick.” Carlos Malvestutto, MD, MPH, who specializes in infectious disease at The Ohio State University Wexner Medical Center

Germany (BioNTech vaccine) and the WHO chose to use the 2003 patented (patent US-2006257852-A1) herpes ORF10 protein encoded SARS-CoV-2 virus to ensure the novel coronavirus would reinfect (relapse) everyone who was vaccinated for years to come. There is currently no cure or preventive treatment for a herpes infection. If a person gets a herpes virus infection, they will have it for life , whether or not they experience symptoms – during the first herpes outbreak (called primary herpes), an infected person may experience flu-like symptoms. These include body aches, fever and headache.

#COVID-19, #mRNAvaccines, #vaccines, #BioNTech, #Moderna, #WHO, #SARS-CoV-2

Human herpes virus protein in genome of SARS-CoV-2 provides evidence the virus that causes COVID-19 was developed for WHO to be used as a bioweapon

SARS-CoV-2 genome annotation revealed the presence of 10 open reading frames (ORFs). SARS-CoV-2 possesses two accessory proteins, ORF8 and ORF10, that share no homology to other coronavirus strains.

The SARS-CoV-2 accessory protein ORF10 (organism Human herpesvirus 8/HHV-8), a putative 38-amino acid viral protein encoded in the 3’ accessory region of the genome, is a highly ordered, hydrophobic (insoluble in water; repelling water) , and thermally stable protein, which contains at least one transmembrane region.

“the ORF10 protein contains high numbers of promiscuous cytotoxic T lymphocyte (CTL) epitopes, primarily on the α-helix. A recent study by Liu et al. 2020 found that in severe cases of COVID-19, the ORF10 was overexpressed when compared against ORF10 expression levels in moderate cases. If the ORF10 protein is synthesized (manufactured, man made), this may help to partially explain the nature behind severe cases of COVID-19. The large number of CTL epitopes in conjunction with the overproduction of the ORF10 protein could result in elevated immune responses towards SARS-CoV-2, leading to some potentially fatal immunopathological outcomes. … Alternatively, ORF10 may act itself or serve as a precursor for other RNAs in regulating gene expression/replication, translation efficiency, or interfering with cellular antiviral pathways.October 2020 study

ORF8, “although non-essential and the precise functions are unknown, it has been suggested that this protein assists in SARS-CoV-2 replication in the early secretory pathway and in immune evasion. … Since ORF8 is not an essential protein for the SARS-CoV-2 life cycle, ORF8 is likely to functionally associate with other SARS-CoV-2 components to assist with SARS-CoV-2 replication and assembly in host cells, but, the coordinated process of this mechanism is still unknown”

“It is also noteworthy that ORF10, exclusively found in SARS-CoV-2 (and not in SARS-CoV), has been shown to interact with the Cullin 2 (CUL2) RING E3 ligase complex, possibly hijacking its function. It is not known what the implications of this interaction is for virus replication, but a similar complex is recruited by other viral proteins, including HIV Vif, Adenovirus E4Orf6, EBV Bzlf and others (Mahon et al., 2014). In all cases, the virus exploits this to target an antiviral protein for proteasome degradation, and it is therefore likely the case also for Orf10.” Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

Accessory proteins (ORF8, ORF10) were suggested to play an important role in virulence and host interaction in other coronaviruses (Liu et al., 2014).

Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome contains

Protein ORF10

Gene

ORF10

Organism

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi’s sarcoma-associated herpesvirus)

Human herpesvirus 8 (HHV-8) is the infectious cause of Kaposi sarcoma (KS) and HIV-infection. HHV-8 infection is not very common in North America. It occurs more often in some Mediterranean countries and is widespread in Africa.

“In the United States, men who have sex with men (MSM) and persons with HIV infection are at increased risk for HHV-8 infection. Among MSM without HIV infection, the seroprevalence ranges from 13% to 20% and HHV-8 seroprevalence increases to 30% to 35% among MSM with HIV infection. Injection drug use may also be a risk factor for HHV-8 seropositivity, although this association has not been consistently observed.”

HHV-8 is etiologically associated with all forms of Kaposi sarcoma (KS) including classic, endemic (belonging or native to a particular people or country), transplant-related, and AIDS-related, as well as rare neoplastic disorders (primary effusion lymphoma [PEL] and solid organ variants) and the lymphoproliferative disorder known as multicentric Castleman’s disease (MCD). Although the precise pathogenesis for these tumors remains unclear, infection with HHV-8 precedes their development.” Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV

The presence of two accessory proteins, ORF8 and ORF10, that share no homology to other coronaviruses strains but appear to assist with SARS-CoV-2 replication and and in immune evasion, suggests SARS-CoV-2 was developed for the strapped for cash WHO as a bioweapon.

ORF10 protein “HHV-8 mostly causes disease mainly in immunocompromised individuals” Johns Hopkins Medicine

Germany’s Pfizer-BioNTech and DARPA funded Moderna COVID-19 vaccines part of UN/WHO’s vaccine induced sterility/genocide program

Messenger RNA (mRNA) is genetic material, so in that sense, the vaccines are genetically based therapy. But the FDA classifies them as vaccines, not gene therapy. Here’s why?

Since 1972 “the WHO Task Force on Vaccines for Fertility Regulation has been supporting basic and clinical research on the development of birth control vaccines directed against the gametes or the preimplantation embryo. These studies have involved the use of advanced procedures in peptide chemistry, hybridoma technology and molecular genetics as well as the evaluation of a number of novel approaches in general vaccinology.” WHO Task Force on Vaccines for Fertility Regulation

The UN/WHO/World Bank’s strategy is for devising a nonsurgical method to induce permanent sterility. That has already been developed and tested.

a nonsurgical method to induce permanent sterility calls for the combined use of a “gene silencing” technology with a “gene therapy” delivery system that can target silencing molecules to specific regions of the brain critical for fertility, and cause long-term suppression of gene expression. Because the vector to be employed remains active for years, permanent sterility is expected to occur following a single systemic administration.

Recently published studies of a gene know as Enhanced at Puberty 1 (EAP1), evidence was provided that RNAi can be used to disrupt reproductive cyclicity in two species of animals, rats and non-human primates. These studies in rats and non-human primates clearly demonstrate that RNAi is capable of disrupting female reproductive cyclicity.Targeted Gene Silencing to Induce Permanent Sterility

“As of June 2020, two of the ten top vaccine candidates used RNAi technology for COVID-19 vaccination. These two vaccines were developed by Moderna and NIAD, and BioNTech and Pfizer.” Yahoo!Finance

The UN/WHO have been conducting vaccine medical experiments since WWII. The UN/WHO continued Nazi Germany’s Auschwitz medical experiment using vaccines. Photo below provides refutable proof – “United Nations personnel vaccinate an 11-year-old concentration camp survivor who was a victim of medical experiments at the Auschwitz camp.”

What the UN/WHO wants and is supporting under the “WHO Task Force on Vaccines for Fertility Regulation” is a very serious crime.  The UN/WHO supporting basic and clinical research on the development of birth control vaccines is defined as genocide.

Convention on the Prevention and Punishment of the Crime of Genocide

Article II

In the present Convention, genocide means any of the following acts committed with intent to destroy, in whole or in part, a national, ethnical, racial or religious group, as such:

  1. Killing members of the group;
  2. Causing serious bodily or mental harm to members of the group;
  3. Imposing measures intended to prevent births within the group;

The intended and stated purpose of the UN/WHO Task Force on Vaccines for Fertility Regulation “has been supporting basic and clinical research on the development of birth control vaccines

The UN/WHO is essentially saying it wants vaccines to be developed to commit genocide. Birth control vaccines are UN/WHO measures intended to prevent births = genocide.

“Genocide is the most heinous of crimes, encompassing all it touches in a tsunami of hate and destruction. It is an assault on our most fundamental shared values.” UN Secretary-general, December 9, 2020 New York

“The Genocide Convention establishes in Article I that the crime of genocide may take place in the context of an armed conflict, international or non-international, but also in the context of a peaceful situation. The latter is less common but still possible. The same article establishes the obligation of the contracting parties to prevent and to punish the crime of genocide” The United Nations Organization

COVID-19 vaccines developed to assist Germany and the WHO prolong COVID-19

“The possibility should be looked into that the immune response to the virus itself may be impaired if the infecting virus damages, more or less selectively the cells responding to the viral antigens. If this proves to be the case, virus-induced immunodepression might conceivably be highly instrumental in prolonging certain virus infections, such as murine leukemia, hepatitis, … ” WHO, From the Bulletin of the World Health Organization, Volume 47, p.259, 1972, Recommendations (3)

The WHO / UN essentially directed virologists to develop ways to impair natural immune responses and prolong virus infections.

COVID-19 vaccines were developed to do just that – prolong SARS-CoV-2 infections. At least 2 vaccines were developed for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) based on a modified vaccinia virus.

“We developed two COVID-19 vaccines based on modified vaccinia virus Ankara (MVA) vectors expressing the entire SARS-CoV-2 spike (S) protein (MVA-CoV2-S)”  Spain virologist Mariano Esteban, from Madrid’s National Biotechnology Center, and by Felipe García, from the Clínic Hospital in Barcelona.

Spain’s experimental COVID-19 vaccines are based on genetic language, RNA, as are Moderna and Germany’s Pfizer-BioNtech vaccines. These vaccines introduce a genetic formula with instructions for human cells to produce the S proteins the novel coronavirus needs and uses to gain entry to our cells and once inside, the virus is free to replicate, making us sick.

The vaccinia virus “function by restricting the production of IFN by blocking the signaling pathways leading to transcription of IFN genes, stopping IFNs binding to their receptors, blocking IFN-induced signal transduction leading to expression of interferon-stimulated genes (ISGs), or inhibiting the antiviral activity of ISG products. – Geoffrey L Smith, University of Cambridge January 2018

Immunological research provides evidence that COVID-19 mRNA vaccines manufactured based on a modified vaccinia virus increases infection:

“Ferrets vaccinated with a modified vaccinia virus Ankara (MVA) vaccine expressing full-length S protein had increased infection and hepatitis following challenge71,72. Antibodies to S protein were reported to induce acute lung injury in experimentally infected macaques on the basis of histological examination.” https://www.nature.com/articles/s41577-020-00434-6

European Commission paper reported COVID-19 vaccine manufacturers Pfizer/BioNtech, Moderna & Astra Zeneca/University of Oxford falsified data – committed fraud

“The candidate vaccines do not prevent SARS-COV-2 infections which makes them suspicious at best and dishonest at best since they were made to elicit immune response that targets the SARS-COV-2 Spike protein. If the immune response that is elicited by the candidate vaccines was truly targeting SARS-COV-2 Spike protein, prevention of SARS-COV-2 infections should have been their primary mechanism of action (SARS-COV-2 should not in principle be able to enter and infect cells). The fact that the candidate vaccines do not prevent SARS-COV-2 infections make the claims of more than 90% effectiveness dubious, misleading at best and dishonest at worse. As stated above, no verifiable scientific evidence is available to show that the candidate vaccines concocted and developed by Pfizer/BioNtech, Moderna and Astra Zeneca/University of Oxford are more than 90% effective. The only way to know anything about the effectiveness of the candidate vaccines is to analyze the data towards the end of the clinical trials in 2022 or to completely unseal the data for all the participants now. There is also no study of the long-term effects of the candidate vaccines. Again, one cannot cut corners when it comes to proving the effectiveness of a candidate vaccine and whether it is dangerous or not.”

CERN EC Journal of Investigative Critiques of Published Scientific Articles.

Website “commissioned by the European Commission to support their nascent Open Data policy by providing a catch-all repository for European Commission funded research” CERN EC Journal of Investigative Critiques of Published Scientific Articles

Source: DISHONEST SCIENTIFIC REPORT AND DATA FALSIFICATION WITH RESPECT TO THE EFFECTIVENESS OF THE CANDIDATE SARS-COV-2/COVID-19 VACCINES DEVELOPED BY BIONTECH/PFIZER, MODERNA AND ASTRAZENECA/UNIVERSITY OF OXFORD

Criminal Code of Canada defines COVID-19 vaccine manufacturers Pfizer/BioNtech, Moderna & Astra Zeneca/University of Oxford falsifying data to obtain regulatory approval and sale or purchase of their vaccines as Fraud

  •  (1) Every one who, by deceit, falsehood or other fraudulent means, whether or not it is a false pretence within the meaning of this Act, defrauds the public or any person, whether ascertained or not, of any property, money or valuable security or any service,

    • (a) is guilty of an indictable offence and liable to a term of imprisonment not exceeding fourteen years, where the subject-matter of the offence is a testamentary instrument or the value of the subject-matter of the offence exceeds five thousand dollars; or

    • (b) is guilty

      • (i) of an indictable offence and is liable to imprisonment for a term not exceeding two years, or

      • (ii) of an offence punishable on summary conviction,

      where the value of the subject-matter of the offence does not exceed five thousand dollars.

The United States’ SEC and FBI defines COVID-19 vaccine manufacturers’ falsifying data as securities fraud.

Generally, securities fraud occurs when someone makes a false statement about a company or the value of its stock, and others makes financial decisions based on the false information.

Securities fraud is a criminal offense that is punishable under 18 USC § 1348. The law has the intention of protecting investors against fraudulent securities, such as stocks and bonds, through the imposition of disclosing important facts related to all forms of trade securities. To become liable for the offense, one must have committed the following acts:

  • Causing to defraud another person related to a commodity transacted for a future delivery. It may include any form of a security that is included in the classification provided by the Securities and Exchange Act.
  • The commission of misrepresentation, false statements, or false promises to obtain anything of value, such as money and property, in relation to a sale or purchase of a commodity.
  • Failure to disclose material facts related to the exchange of securities and provide false statements instead.